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Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.

Abstract:

1. We have investigated the mechanism of action of the novel anti-diabetic agent mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium (K(ATP)) channel. These possess a common pore-forming subunit, Kir6.2, and different regulatory sulphonylurea receptor (SUR) subunits. It is believed that they correspond to native K(ATP) channels in pancreatic beta-cells, heart and non-vascular smooth muscle, respectively. 2. Kir6.2 was coexpressed with SUR1, SUR...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjp.0703962

Authors


Reimann, F More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
British journal of pharmacology
Volume:
132
Issue:
7
Pages:
1542-1548
Publication date:
2001-04-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:04ec9bbe-5af7-4703-89b8-5cc3e6fde7ee
Source identifiers:
113990
Local pid:
pubs:113990

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