- Abstract:
-
1. We have investigated the mechanism of action of the novel anti-diabetic agent mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium (K(ATP)) channel. These possess a common pore-forming subunit, Kir6.2, and different regulatory sulphonylurea receptor (SUR) subunits. It is believed that they correspond to native K(ATP) channels in pancreatic beta-cells, heart and non-vascular smooth muscle, respectively. 2. Kir6.2 was coexpressed with SUR1, SUR...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/sj.bjp.0703962
-
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- Journal:
- British journal of pharmacology
- Volume:
- 132
- Issue:
- 7
- Pages:
- 1542-1548
- Publication date:
- 2001-04-05
- DOI:
- EISSN:
-
1476-5381
- ISSN:
-
0007-1188
- URN:
-
uuid:04ec9bbe-5af7-4703-89b8-5cc3e6fde7ee
- Source identifiers:
-
113990
- Local pid:
- pubs:113990
- Copyright date:
- 2001
Journal article
Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.
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