Natural killer cells and spontaneous cell-mediated cytotoxicity in the human intestine.

Journal article

Spontaneous cell-mediated cytotoxicity (SCMC) has been investigated in mononuclear cells (MNC) isolated from intestinal mucosa and autologous peripheral blood from human subjects. The proportion of cells with the NK-K phenotype (Leu 7+) were substantially lower in intestinal MNC than in autologous peripheral blood. SCMC of K-562 target cells when tested at an effector to target (E:T) ratio equivalent to that used for peripheral blood MNC was markedly deficient in intestinal MNC. This was not ...

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Authors: Gibson, P; Dow, E; Selby, W; Strickland, R; Jewell, D

• Publication status: Published
• Journal: Clinical and experimental immunology
• Volume: 56
• Issue: 2
• Pages: 438-444
• Publication date: 1984-05-01
• EISSN: 1365-2249
• ISSN: 0009-9104
• Language: English
• Keywords: Colon; Humans; Cytotoxicity, Immunologic; Intestinal Diseases; Killer Cells, Natural; Intestinal Mucosa