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Crystal structures of type-II inositol polyphosphate 5-phosphatase INPP5B with synthetic inositol polyphosphate surrogates reveal new mechanistic insights for the inositol 5-phosphatase family

Abstract:

The inositol polyphosphate 5-phosphatase INPP5B hydrolyzes the 5-phosphate group from water- and lipid-soluble signaling messengers. Two synthetic benzene and biphenyl polyphosphates (BzP/BiPhPs), simplified surrogates of inositol phosphates and phospholipid headgroups, were identified by thermodynamic studies as potent INPP5B ligands. The X-ray structure of the complex between INPP5B and biphenyl 3,3,4,4,5,5-hexakisphosphate [BiPh(3,3,4,4,5,5)P6, IC50 5.5 µM] was determined at 2.89Å re...

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Publication status:
In press
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/acs.biochem.5b00838

Authors


Silvander, C More by this author
Trésaugues, L More by this author
Nordlund, P More by this author
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More from this funder
Funding agency for:
Potter, BVL
Swedish Cancer Society More from this funder
Swedish Research Council More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Biochemistry Journal website
Publication date:
2016
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:04e4b3fa-73bd-4cdf-b6c5-2855e29bb3f5
Source identifiers:
601631
Local pid:
pubs:601631

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