- Abstract:
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The inositol polyphosphate 5-phosphatase INPP5B hydrolyzes the 5-phosphate group from water- and lipid-soluble signaling messengers. Two synthetic benzene and biphenyl polyphosphates (BzP/BiPhPs), simplified surrogates of inositol phosphates and phospholipid headgroups, were identified by thermodynamic studies as potent INPP5B ligands. The X-ray structure of the complex between INPP5B and biphenyl 3,3,4,4,5,5-hexakisphosphate [BiPh(3,3,4,4,5,5)P6, IC50 5.5 µM] was determined at 2.89Å re...
Expand abstract - Publication status:
- In press
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Publisher copy:
- 10.1021/acs.biochem.5b00838
-
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- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Biochemistry Journal website
- Publication date:
- 2016
- DOI:
- EISSN:
-
1520-4995
- ISSN:
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0006-2960
- URN:
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uuid:04e4b3fa-73bd-4cdf-b6c5-2855e29bb3f5
- Source identifiers:
-
601631
- Local pid:
- pubs:601631
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2016
Journal article
Crystal structures of type-II inositol polyphosphate 5-phosphatase INPP5B with synthetic inositol polyphosphate surrogates reveal new mechanistic insights for the inositol 5-phosphatase family
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Swedish Cancer Society
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