The role of T-cell receptor dimerization in T-cell activation.

Journal article

T-cell specificity is encoded in single T-cell receptors (TCRs) but monovalent interactions with peptide bound to the major histocompatibility complex (MHC) may not sufficiently account for the complexities associated with T-cell activation. This review proposes that TCRs undergo dimerization before activation and that this property might be essential for both T-cell antagonism and T-cell specificity, and may be pivotal for T-cell survival versus T-cell activation.

Authors: Bachmann, M; Ohashi, P

• Publication status: Published
• Journal: Immunology today
• Volume: 20
• Issue: 12
• Pages: 568-576
• Publication date: 1999-12-01
• DOI: 10.1016/s0167-5699(99)01543-1
• ISSN: 0167-5699
• Language: English
• Keywords: Models, Immunological; Signal Transduction; T-Lymphocytes, Cytotoxic; Endocytosis; Receptors, Antigen, T-Cell; Lymphocyte Activation; Dimerization; Animals; Ligands; Rats; Peptide Fragments