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Journal article

C3 metabolism in ulcerative colitis and Crohn's disease.

Abstract:
The metabolism of the third component of complement (C3) has been investigated in four patients with ulcerative colitis, three patients with Crohn's disease and seven control subjects, using radioiodinated C3 prepared from fresh human plasma. Both the fractional catabolic rate and synthesis rate of C3 were increased in the patients with inflammatory bowel disease, although the serum-C3 levels were normal or raised. The results suggest that complement activation may play a role in the pathogenesis of mucosal inflammation in these diseases.
Publication status:
Published

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Journal:
Clinical and experimental immunology
Volume:
28
Issue:
3
Pages:
490-495
Publication date:
1977-06-01
EISSN:
1365-2249
ISSN:
0009-9104
Source identifiers:
165801
Language:
English
Keywords:
Pubs id:
pubs:165801
UUID:
uuid:04de75d2-a655-49d8-9632-f38b49214cd0
Local pid:
pubs:165801
Deposit date:
2012-12-19

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