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Characterisation of light responses in the retina of mice lacking principle components of rod, cone and melanopsin phototransduction signalling pathways.

Abstract:

Gnat−/−, Cnga3−/−, Opn4−/− triple knockout (TKO) mice lack essential components of phototransduction signalling pathways present in rods, cones and photosensitive retinal ganglion cells (pRGCs), and are therefore expected to lack all sensitivity to light. However, a number of studies have shown that light responses persist in these mice. In this study we use multielectrode array (MEA) recordings and light-induced c-fos expression to further characterise the light responses of the TKO retina. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep28086

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
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Funding agency for:
Foster, RG
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
Article: 28086
Publication date:
2016-06-05
DOI:
ISSN:
2045-2322
URN:
uuid:04dd46db-58f4-44be-ad78-75a4596fb18e
Source identifiers:
627016
Local pid:
pubs:627016

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