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Does Amifostine reduce metabolic rate? Effect of the drug on gas exchange and acute ventilatory hypoxic response in humans

Abstract:

Amifostine is added to chemoradiation regimens in the treatment of many cancers on the basis that, by reducing the metabolic rate, it protects normal cells from toxic effects of therapy. We tested this hypothesis by measuring the metabolic rate (by gas exchange) over 255 min in 6 healthy subjects, at two doses (500 mg and 1000 mg) of amifostine infused over 15 min at the start of the protocol. We also assessed the ventilatory response to six 1 min exposures to isocapnic hypoxia mid-protocol. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3390/ph8020186

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Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Anaesthetics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Anaesthetics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Department of Physiology, Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, Weatherall Institute of Molecular Medicine
Role:
Author
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Publisher:
MDPI Publisher's website
Journal:
Pharmaceuticals Journal website
Volume:
8
Issue:
2
Pages:
186-195
Publication date:
2015-04-16
DOI:
EISSN:
1424-8247
URN:
uuid:04da652b-31d9-4bf3-b01c-b20b26d8a2b9
Source identifiers:
518959
Local pid:
pubs:518959

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