- Abstract:
-
Amifostine is added to chemoradiation regimens in the treatment of many cancers on the basis that, by reducing the metabolic rate, it protects normal cells from toxic effects of therapy. We tested this hypothesis by measuring the metabolic rate (by gas exchange) over 255 min in 6 healthy subjects, at two doses (500 mg and 1000 mg) of amifostine infused over 15 min at the start of the protocol. We also assessed the ventilatory response to six 1 min exposures to isocapnic hypoxia mid-protocol. ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 334.1KB)
-
- Publisher copy:
- 10.3390/ph8020186
-
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- Publisher:
- MDPI Publisher's website
- Journal:
- Pharmaceuticals Journal website
- Volume:
- 8
- Issue:
- 2
- Pages:
- 186-195
- Publication date:
- 2015-04-16
- DOI:
- EISSN:
-
1424-8247
- URN:
-
uuid:04da652b-31d9-4bf3-b01c-b20b26d8a2b9
- Source identifiers:
-
518959
- Local pid:
- pubs:518959
- Copyright holder:
- Pandit et al.
- Copyright date:
- 2015
- Notes:
-
Copyright © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution license
(http://creativecommons.org/licenses/by/4.0/).
Journal article
Does Amifostine reduce metabolic rate? Effect of the drug on gas exchange and acute ventilatory hypoxic response in humans
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Difficult Airway Society
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