Journal article
Does Amifostine reduce metabolic rate? Effect of the drug on gas exchange and acute ventilatory hypoxic response in humans
- Abstract:
-
Amifostine is added to chemoradiation regimens in the treatment of many cancers on the basis that, by reducing the metabolic rate, it protects normal cells from toxic effects of therapy. We tested this hypothesis by measuring the metabolic rate (by gas exchange) over 255 min in 6 healthy subjects, at two doses (500 mg and 1000 mg) of amifostine infused over 15 min at the start of the protocol. We also assessed the ventilatory response to six 1 min exposures to isocapnic hypoxia mid-protocol. ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(pdf, 334.1KB)
-
- Publisher copy:
- 10.3390/ph8020186
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Difficult Airway Society
More from this funder
Bibliographic Details
- Publisher:
- MDPI Publisher's website
- Journal:
- Pharmaceuticals Journal website
- Volume:
- 8
- Issue:
- 2
- Pages:
- 186-195
- Publication date:
- 2015-04-16
- DOI:
- EISSN:
-
1424-8247
- Source identifiers:
-
518959
Item Description
- Keywords:
- Pubs id:
-
pubs:518959
- UUID:
-
uuid:04da652b-31d9-4bf3-b01c-b20b26d8a2b9
- Local pid:
- pubs:518959
- Deposit date:
- 2015-04-24
Terms of use
- Copyright holder:
- Pandit et al
- Copyright date:
- 2015
- Notes:
-
Copyright © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution license
(http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record