Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury.

Journal article

Alveolar type II (ATII) cell proliferation and differentiation are important mechanisms in repair following injury to the alveolar epithelium. KGF is a potent ATII cell mitogen, which has been demonstrated to be protective in a number of animal models of lung injury. We have assessed the effect of recombinant human KGF (rhKGF) and liposome-mediated KGF gene delivery in vivo and evaluated the potential of KGF as a therapy for acute lung injury in mice. rhKGF was administered intratracheally in...

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Authors: Ulrich, K; Stern, M; Goddard, M; Williams, J; Zhu, J

• Journal: American journal of physiology. Lung cellular and molecular physiology
• Volume: 288
• Issue: 6
• Pages: L1179-L1192
• Publication date: 2005-06-01
• DOI: 10.1152/ajplung.00450.2004
• EISSN: 1522-1504
• ISSN: 1040-0605
• Language: English
• Keywords: Pulmonary Surfactant-Associated Protein B; Lung Diseases; Recombinant Proteins; Fibroblast Growth Factors; Animals; Lung Injury; Fibroblast Growth Factor 7; Mice; Male; Oleic Acid; Humans; Pulmonary Alveoli; Cell Differentiation; Keratinocytes; Mice, Inbred BALB C; Cell Proliferation; Acute Disease