Pharmacokinetics and clinical effect of phenobarbital in children with severe falciparum malaria and convulsions.

Journal article

AIMS: Phenobarbital is commonly used to treat status epilepticus in resource-poor countries. Although a dose of 20 mg kg(-1) is recommended, this dose, administered intramuscularly (i.m.) for prophylaxis, is associated with an increase in mortality in children with cerebral malaria. We evaluated a 15-mg kg(-1) intravenous (i.v.) dose of phenobarbital to determine its pharmacokinetics and clinical effects in children with severe falciparum malaria and status epilepticus. METHODS: Twelve child...

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Authors: Kokwaro, G; Ogutu, B; Muchohi, SN; Otieno, G; Newton, C

• Publication status: Published
• Journal: British journal of clinical pharmacology
• Volume: 56
• Issue: 4
• Pages: 453-457
• Publication date: 2003-10-01
• DOI: 10.1046/j.1365-2125.2003.01951.x
• EISSN: 1365-2125
• ISSN: 0306-5251
• Language: English
• Keywords: Infant; Male; Dose-Response Relationship, Drug; Status Epilepticus; Infusions, Intravenous; Female; Phenobarbital; Anticonvulsants; Malaria, Falciparum; Child, Preschool; Malaria, Cerebral; Seizures; Recurrence; Humans