Assay for screening for six antimalarial drugs and one metabolite using dried blood spot sampling, sequential extraction and ion-trap detection.

Journal article

BACKGROUND: More parasites are becoming resistant to antimalarial drugs, and in many areas a change in first-line drug treatment is necessary. The aim of the developed assay is to help determine drug use in these areas and also to be a complement to interviewing patients, which will increase reliability of surveys. RESULTS: This assay detects quinine, mefloquine, sulfadoxine, pyrimethamine, lumefantrine, chloroquine and its metabolite desethylchloroquine in a 100-µl dried blood spot. Most of...

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Authors: Blessborn, D; Romsing, S; Bergqvist, Y; Lindegardh, N

• Publication status: Published
• Journal: Bioanalysis
• Volume: 2
• Issue: 11
• Pages: 1839-1847
• Publication date: 2010-11-01
• DOI: 10.4155/bio.10.147
• EISSN: 1757-6199
• ISSN: 1757-6180
• Language: English
• Keywords: Chromatography, Liquid; Antimalarials; Blood Specimen Collection; Time Factors; Mass Spectrometry; Blood Chemical Analysis; Desiccation; Chemical Fractionation; Humans