Interferon gamma (IFNγ) supports effector responses of CD8+ cytotoxic T lymphocytes (CTLs) and is a surrogate marker for detection of antigen-specific T cells. Here, we show that tumor-specific CTL clones have impaired IFNγ expression and production upon activation. Assessment of the relationship between IFNγ production and the 5′methylcytosine-guanine (CpG) dinucleotide methylation of the IFNγ promoter using bisulfite treatment has shown that IFNγ− CTL clones accumulates CpG hypermethylation...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Copyright holder:
- Abd Hamid, M et al.
- Rights statement:
- © 2020 Abd Hamid, Yao, Waugh, Rosendo-Machado, Li, Rostron, Frankland, Peng and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- CC Attribution (CC BY)
Defective interferon gamma production by tumor-specific cd8+ T cells is associated with 5′methylcytosine-guanine hypermethylation of interferon gamma promoter
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