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Defective interferon gamma production by tumor-specific cd8+ T cells is associated with 5′methylcytosine-guanine hypermethylation of interferon gamma promoter

Abstract:

Interferon gamma (IFNγ) supports effector responses of CD8+ cytotoxic T lymphocytes (CTLs) and is a surrogate marker for detection of antigen-specific T cells. Here, we show that tumor-specific CTL clones have impaired IFNγ expression and production upon activation. Assessment of the relationship between IFNγ production and the 5′methylcytosine-guanine (CpG) dinucleotide methylation of the IFNγ promoter using bisulfite treatment has shown that IFNγ− CTL clones accumulates CpG hypermethylation...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Subgroup:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Subgroup:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Subgroup:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Grant:
MR/P021336/1 Crick code 10590
John Fell Fund More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
11
Article number:
310
Publication date:
2020-03-05
Acceptance date:
2020-02-07
DOI:
EISSN:
1664-3224
Pubs id:
1091113
Local pid:
pubs:1091113

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