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A prospective evaluation of real-time PCR assays for the detection of Orientia tsutsugamushi and Rickettsia spp. for early diagnosis of rickettsial infections during the acute phase of undifferentiated febrile illness.

Abstract:

One hundred and eighty febrile patients were analyzed in a prospective evaluation of Orientia tsutsugamushi and Rickettsia spp. real-time polymerase chain reaction (PCR) assays for early diagnosis of rickettsial infections. By paired serology, 3.9% (7 of 180) and 6.1% (11 of 180) of patients were confirmed to have acute scrub or murine typhus, respectively. The PCR assays for the detection of O. tsutsugamushi and Rickettsia spp. had high specificity (99.4% [95% confidence interval (CI): 96.8-...

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Publication status:
Published

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Publisher copy:
10.4269/ajtmh.12-0600

Authors


Watthanaworawit, W More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Tanganuchitcharnchai, A More by this author
Richards, AL More by this author
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Journal:
The American journal of tropical medicine and hygiene
Volume:
89
Issue:
2
Pages:
308-310
Publication date:
2013-08-05
DOI:
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:04c92b2a-fe38-44b2-91e3-8269a6fe2e46
Source identifiers:
401441
Local pid:
pubs:401441

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