Journal article
Modelling the evolution and spread of HIV immune escape mutants.
- Abstract:
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During infection with human immunodeficiency virus (HIV), immune pressure from cytotoxic T-lymphocytes (CTLs) selects for viral mutants that confer escape from CTL recognition. These escape variants can be transmitted between individuals where, depending upon their cost to viral fitness and the CTL responses made by the recipient, they may revert. The rates of within-host evolution and their concordant impact upon the rate of spread of escape mutants at the population level are uncertain. Her...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 724.8KB)
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- Publisher copy:
- 10.1371/journal.ppat.1001196
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Authors
Funding
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS pathogens Journal website
- Volume:
- 6
- Issue:
- 11
- Pages:
- e1001196
- Publication date:
- 2010-01-01
- DOI:
- EISSN:
-
1553-7374
- ISSN:
-
1553-7366
- Source identifiers:
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103631
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:103631
- UUID:
-
uuid:04c8cccd-5b22-4721-b27c-9c3e710e9a78
- Local pid:
- pubs:103631
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Fryer et al
- Copyright date:
- 2010
- Notes:
- © 2010 Fryer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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