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Modelling the evolution and spread of HIV immune escape mutants.

Abstract:

During infection with human immunodeficiency virus (HIV), immune pressure from cytotoxic T-lymphocytes (CTLs) selects for viral mutants that confer escape from CTL recognition. These escape variants can be transmitted between individuals where, depending upon their cost to viral fitness and the CTL responses made by the recipient, they may revert. The rates of within-host evolution and their concordant impact upon the rate of spread of escape mutants at the population level are uncertain. Her...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1001196

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Role:
Author
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Funding agency for:
Fryer, HR
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Funding agency for:
Phillips, RE
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
6
Issue:
11
Pages:
e1001196
Publication date:
2010-01-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:04c8cccd-5b22-4721-b27c-9c3e710e9a78
Source identifiers:
103631
Local pid:
pubs:103631

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