Journal article

Unusual antigen presentation offers new insight into HIV vaccine design

Abstract:: Recent findings with a rhesus monkey cytomegalovirus based simian immunodeficiency virus vaccine have identified strong CD8+ T cell responses that are restricted by MHC-E. Also mycobacteria specific CD8+ T cells, that are MHC-E restricted, have been identified. MHC-E therefore can present a wide range of epitope peptides to CD8+ T cells, alongside its well defined role in presenting a conserved MHC-class I signal peptide to the NKG2A/C-CD94 receptor on natural killer cells. Here we explore the antigen processing pathways involved in these atypical T cell responses.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

McMichael, A., & Picker, L. (2017). Unusual antigen presentation offers new insight into HIV vaccine design. Current Opinion in Immunology, 46, 75–81.

MLA Style

McMichael, A., and L. Picker. “Unusual Antigen Presentation Offers New Insight into HIV Vaccine Design.” Current Opinion in Immunology, vol. 46, Elsevier, 2017, pp. 75–81.

Chicago Style

McMichael, A, and L Picker. 2017. “Unusual Antigen Presentation Offers New Insight into HIV Vaccine Design.” Current Opinion in Immunology 46: 75–81.
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Files:: Current Op Review-Jan 10.pdf

(Preview, Accepted manuscript, pdf, 424.5KB, Terms of use)

Publisher copy:: 10.1016/j.coi.2017.04.009

Authors

+ McMichael, A More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Target Discovery Institute
Oxford college:: Corpus Christi College
Role:: Author

+ Picker, L More by this author

Role:: Author

+ NIH HHS More from this funder

Grant:: P51 OD011092

+ NIAID NIH HHS More from this funder

Grant:: P01 AI094417; UM1 AI100645; R37 AI054292; U19 AI095985; U19 AI096109; R01 AI054292

+ Medical Research Council More from this funder

Grant:: MR/K012037/1

Publisher:: Elsevier
Journal:: Current Opinion in Immunology More from this journal
Volume:: 46
Pages:: 75-81
Publication date:: 2017-05-12
Acceptance date:: 2017-04-17
DOI:: 10.1016/j.coi.2017.04.009
EISSN:: 1879-0372
ISSN:: 0952-7915
Pmid:: 28505602

Language:: English
Keywords:: FFR
Pubs id:: pubs:695939
UUID:: uuid:04c75f52-722e-415a-8487-709a7f8355f4
Local pid:: pubs:695939
Source identifiers:: 695939
Deposit date:: 2019-03-01

Terms of use

Copyright holder:: Elsevier
Copyright date:: 2017
Notes:: Copyright © 2017 Elsevier Ltd. All rights reserved. A correction to this article is available at; https://doi.org/10.1016/j.coi.2018.08.006

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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