Journal article
A single dose of anti-miR-122, RG-101, in CHC patients results in NK cell normalization with no effect on HCV-specific CD8+ T cell function
- Abstract:
-
MicroRNA-122 (miR-122) is an important host factor for the hepatitis C virus. Treatment with RG-101, a GalNAc conjugated anti-miR-122 oligonucleotide, resulted in a significant viral load reduction in patients with chronic hepatitis C (CHC) infection. Here, we analyzed the effects of RG-101 therapy on antiviral immunity. 32 CHC patients HCV genotype 1, 3 and 4 received a single subcutaneous administration with RG-101 at 2 mg/kg (n=14), 4 mg/kg (n=14) or placebo (n=2 per dosing group). Plasma ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Medical Research Council
More from this funder
Funding agency for:
Klenerman, P
Grant:
U19AI082630
+ National Institute for Health Research
More from this funder
Funding agency for:
Klenerman, P
Grant:
U19AI082630
+ National Institutes of Health
More from this funder
Funding agency for:
Klenerman, P
Grant:
U19AI082630
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Hepatology Journal website
- Volume:
- 66
- Issue:
- 1
- Pages:
- 57–68
- Publication date:
- 2017-03-01
- Acceptance date:
- 2017-02-14
- DOI:
- EISSN:
-
1527-3350
- ISSN:
-
0270-9139
- Source identifiers:
-
680422
Item Description
- Keywords:
- Pubs id:
-
pubs:680422
- UUID:
-
uuid:04bf4fe8-6846-43b1-859a-3c83422a947d
- Local pid:
- pubs:680422
- Deposit date:
- 2017-02-16
Terms of use
- Copyright holder:
- American Association for the Study of Liver Diseases
- Copyright date:
- 2017
- Notes:
- © 2017 by the American Association for the Study of Liver Diseases
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