Journal article
A single dose of anti-miR-122, RG-101, in CHC patients results in NK cell normalization with no effect on HCV-specific CD8+ T cell function
- Abstract:
-
MicroRNA-122 (miR-122) is an important host factor for the hepatitis C virus. Treatment with RG-101, a GalNAc conjugated anti-miR-122 oligonucleotide, resulted in a significant viral load reduction in patients with chronic hepatitis C (CHC) infection. Here, we analyzed the effects of RG-101 therapy on antiviral immunity. 32 CHC patients HCV genotype 1, 3 and 4 received a single subcutaneous administration with RG-101 at 2 mg/kg (n=14), 4 mg/kg (n=14) or placebo (n=2 per dosing group). Plasma ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 749.7KB)
-
- Publisher copy:
- 10.1002/hep.29148
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
+ Medical Research Council
More from this funder
Funding agency for:
Klenerman, P
Grant:
U19AI082630
+ National Institute for Health Research
More from this funder
Funding agency for:
Klenerman, P
Grant:
U19AI082630
+ National Institutes of Health
More from this funder
Funding agency for:
Klenerman, P
Grant:
U19AI082630
Expand funders...
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Hepatology Journal website
- Volume:
- 66
- Issue:
- 1
- Pages:
- 57–68
- Publication date:
- 2017-03-01
- Acceptance date:
- 2017-02-14
- DOI:
- EISSN:
-
1527-3350
- ISSN:
-
0270-9139
- Source identifiers:
-
680422
Item Description
- Keywords:
- Pubs id:
-
pubs:680422
- UUID:
-
uuid:04bf4fe8-6846-43b1-859a-3c83422a947d
- Local pid:
- pubs:680422
- Deposit date:
- 2017-02-16
Terms of use
- Copyright holder:
- American Association for the Study of Liver Diseases
- Copyright date:
- 2017
- Notes:
- © 2017 by the American Association for the Study of Liver Diseases
If you are the owner of this record, you can report an update to it here: Report update to this record