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Journal article

A single dose of anti-miR-122, RG-101, in CHC patients results in NK cell normalization with no effect on HCV-specific CD8+ T cell function

Abstract:

MicroRNA-122 (miR-122) is an important host factor for the hepatitis C virus. Treatment with RG-101, a GalNAc conjugated anti-miR-122 oligonucleotide, resulted in a significant viral load reduction in patients with chronic hepatitis C (CHC) infection. Here, we analyzed the effects of RG-101 therapy on antiviral immunity. 32 CHC patients HCV genotype 1, 3 and 4 received a single subcutaneous administration with RG-101 at 2 mg/kg (n=14), 4 mg/kg (n=14) or placebo (n=2 per dosing group). Plasma ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/hep.29148

Authors


van der Ree, MH More by this author
Sinnige, MJ More by this author
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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Funding agency for:
Klenerman, P
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Funding agency for:
Klenerman, P
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Funding agency for:
Klenerman, P
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Publisher:
Wiley Publisher's website
Journal:
Hepatology Journal website
Volume:
66
Issue:
1
Pages:
57–68
Publication date:
2017-03-05
Acceptance date:
2017-02-14
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
Pubs id:
pubs:680422
URN:
uri:04bf4fe8-6846-43b1-859a-3c83422a947d
UUID:
uuid:04bf4fe8-6846-43b1-859a-3c83422a947d
Local pid:
pubs:680422

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