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Investigation into the onset and progression of transplant arteriosclerosis in a mice aortic retransplantation model.

Abstract:

Long-term function of vascularized human organ grafts is often limited by transplant arteriosclerosis and can lead to graft failure. Here, we have analyzed the impact of an initial rejection episode on the later development of transplant arteriosclerosis. Following transplantation of allogeneic abdominal aortic segments in mice, aortic grafts were retransplanted into either immunodeficient or syngeneic recipients. Retransplantation of grafts from immunocompetent into immunodeficient mice as e...

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Publication status:
Published

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Publisher copy:
10.1002/micr.20477

Authors


Ensminger, S More by this author
Bushell, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Journal:
Microsurgery
Volume:
28
Issue:
3
Pages:
182-186
Publication date:
2008
DOI:
EISSN:
1098-2752
ISSN:
0738-1085
URN:
uuid:04b9952a-20da-4b8f-9c6d-ebe2f6c6b2bc
Source identifiers:
135976
Local pid:
pubs:135976

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