AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.

Journal article

The beta-adrenergic receptor/cyclic AMP/protein kinase A (PKA) signalling pathway regulates heart rate and contractility. Here, we identified a supramolecular complex consisting of the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2), its negative regulator phospholamban (PLN), the A-kinase anchoring protein AKAP18delta and PKA. We show that AKAP18delta acts as a scaffold that coordinates PKA phosphorylation of PLN and the adrenergic effect on Ca(2+) re-uptake. Inhibition of the compartmentaliza...

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Authors: Lygren, B; Carlson, C; Santamaria, K; Lissandron, V; McSorley, T

• Journal: EMBO reports
• Volume: 8
• Issue: 11
• Pages: 1061-1067
• Publication date: 2007-11-01
• DOI: 10.1038/sj.embor.7401081
• EISSN: 1469-3178
• ISSN: 1469-221X
• Language: English
• Keywords: Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; A Kinase Anchor Proteins; Myocytes, Cardiac; Sequence Alignment; Calcium; Multiprotein Complexes; Molecular Sequence Data; Animals; Carrier Proteins; Rats; Calcium-Binding Proteins; Adaptor Proteins, Signal Transducing; Cyclic AMP-Dependent Protein Kinases; Amino Acid Sequence; Membrane Proteins