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Frontal cortical synaptophysin in Lewy body diseases: relation to Alzheimer's disease and dementia.

Abstract:

OBJECTIVES: Dementia in Alzheimer's disease correlates closely with loss of neocortical synapses. Similar synaptic loss has been shown in patients whose Alzheimer's disease is also associated with neocortical and brain stem Lewy bodies. The aim was to determine if dementia in Lewy body disease was associated with diminished concentrations of midfrontal cortex synaptophysin. METHODS: An immunobinding assay was used to measure synaptophysin in postmortem samples of midfrontal cortex from 89 pat...

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Publication status:
Published

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Publisher copy:
10.1136/jnnp.64.5.653

Authors


Hansen, LA More by this author
Daniel, SE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Journal of neurology, neurosurgery, and psychiatry
Volume:
64
Issue:
5
Pages:
653-656
Publication date:
1998-05-05
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
URN:
uuid:049a3c05-e96d-4d7d-b16a-d82b4dac4fae
Source identifiers:
36186
Local pid:
pubs:36186

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