Journal article
Quinine pharmacokinetics in cerebral malaria: predicted plasma concentrations after rapid intravenous loading using a two-compartment model.
- Abstract:
-
To investigate the toxic potential of rapid intravenous quinine administration in severe malaria, the pharmacokinetic properties of low-dose quinine dihydrochloride injection (4 mg/kg body weight, equivalent to 3.3 mg base/kg) followed one hour later by infusion of 16 mg/kg over 3 h were studied in 7 patients with cerebral malaria. Plasma quinine concentrations closely followed a bi-exponential decline. Both the volumes of the central compartment (mean +/- SD: 0.17 +/- 0.10 litre/kg) and tota...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Volume:
- 82
- Issue:
- 4
- Pages:
- 542-547
- Publication date:
- 1988-01-01
- DOI:
- EISSN:
-
1878-3503
- ISSN:
-
0035-9203
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:42997
- UUID:
-
uuid:0499d9a2-0202-4ebb-9b1a-f883057aef9c
- Local pid:
- pubs:42997
- Source identifiers:
-
42997
- Deposit date:
- 2012-12-19
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- Copyright date:
- 1988
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