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Clinical relevance of positive voltage-gated potassium channel (VGKC)-complex antibodies: experience from a tertiary referral centre.

Abstract:

BACKGROUND: Voltage-gated potassium channel (VGKC)-complex antibodies can be associated with a range of immunotherapy-responsive clinical presentations including limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. However, there are patients with positive levels in whom the significance is uncertain. OBJECTIVE: To evaluate the clinical significance associated with positive (>100 pM) VGKC-complex antibodies. METHODS: Over a 4-year period, 1053 samples were sent for testing of...

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Publication status:
Published

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Publisher copy:
10.1136/jnnp-2013-305218

Authors


Paterson, RW More by this author
Armstrong, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Schott, JM More by this author
Journal:
Journal of neurology, neurosurgery, and psychiatry
Volume:
85
Issue:
6
Pages:
625-630
Publication date:
2014-06-05
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
URN:
uuid:049382ae-7c55-4b10-8d20-7feef954dbc0
Source identifiers:
416866
Local pid:
pubs:416866

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