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Journal article

Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing

Abstract:

BACKGROUND: Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral metastases. The molecular nature of DTCs remains elusive, as well as when and from where in the tumor they originate. Here, we apply single-cell sequencing to identify and trace the origin of DTCs in breast cancer. RESULTS: We sequence the genomes of 63 single cells isolated from six non-m...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13059-016-1109-7

Authors


Demeulemeester, J More by this author
Møller, EK More by this author
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Stiftelsen Kristian Gerhard Jebsen More from this funder
Norges Forskningsråd More from this funder
Kreftforeningen More from this funder
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Grant:
grant 39518 to BN and grant 2729004 to VNK
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Grant:
FWO–G.0687.12 to TV and PVL
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Publisher:
BioMed Central Publisher's website
Journal:
Genome Biology Journal website
Volume:
17
Issue:
1
Pages:
Article: 250
Publication date:
2016-12-09
DOI:
EISSN:
1474-760X
ISSN:
1474-7596
Pubs id:
pubs:693578
URN:
uri:04926202-0a15-465d-8002-3cd14e4c2d91
UUID:
uuid:04926202-0a15-465d-8002-3cd14e4c2d91
Local pid:
pubs:693578

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