- Abstract:
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BACKGROUND: Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral metastases. The molecular nature of DTCs remains elusive, as well as when and from where in the tumor they originate. Here, we apply single-cell sequencing to identify and trace the origin of DTCs in breast cancer. RESULTS: We sequence the genomes of 63 single cells isolated from six non-m...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.2mb)
-
- Publisher copy:
- 10.1186/s13059-016-1109-7
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- Grant:
- grant 39518 to BN and grant 2729004 to VNK
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Genome Biology Journal website
- Volume:
- 17
- Issue:
- 1
- Pages:
- Article: 250
- Publication date:
- 2016-12-09
- DOI:
- EISSN:
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1474-760X
- ISSN:
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1474-7596
- Pubs id:
-
pubs:693578
- URN:
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uri:04926202-0a15-465d-8002-3cd14e4c2d91
- UUID:
-
uuid:04926202-0a15-465d-8002-3cd14e4c2d91
- Local pid:
- pubs:693578
- Language:
- English
- Keywords:
- Copyright holder:
- Demeulemeester et al.
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 The Authors. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Journal article
Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing
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Stiftelsen Kristian Gerhard Jebsen
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Norges Forskningsråd
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Kreftforeningen
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+ South-Eastern Norway Regional Health Authority
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