A PAR-1-dependent orientation gradient of dynamic microtubules directs posterior cargo transport in the Drosophila oocyte.

Journal article

Cytoskeletal organization is central to establishing cell polarity in various cellular contexts, including during messenger ribonucleic acid sorting in Drosophila melanogaster oocytes by microtubule (MT)-dependent molecular motors. However, MT organization and dynamics remain controversial in the oocyte. In this paper, we use rapid multichannel live-cell imaging with novel image analysis, tracking, and visualization tools to characterize MT polarity and dynamics while imaging posterior cargo ...

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Authors: Parton, R; Hamilton, R; Ball, G; Yang, L; Cullen, C

• Publication status: Published
• Journal: Journal of cell biology
• Volume: 194
• Issue: 1
• Pages: 121-135
• Publication date: 2011-07-01
• DOI: 10.1083/jcb.201103160
• EISSN: 1540-8140
• ISSN: 0021-9525
• Language: English
• Keywords: Oocytes; Protein-Serine-Threonine Kinases; Animals; Glycogen Synthase Kinase 3; Drosophila melanogaster; Drosophila Proteins; Biological Transport; Microtubules