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Genetic regulation of acquired immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa.

Abstract:

The role of genetic factors in clinical tuberculosis is increasingly recognized; how such factors regulate the immune response to Mycobacterium tuberculosis in healthy individuals is unclear. In this study of 255 adult twin pairs residing in The Gambia, West Africa, it is apparent that memory T-cell responses to secreted mycobacterial antigens (85-kDa antigen complex, "short-term culture filtrate," and peptides from the ESAT-6 protein), as well as to the 65-kDa heat shock protein, are subject...

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Publication status:
Published

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Journal:
Infection and immunity
Volume:
69
Issue:
6
Pages:
3989-3994
Publication date:
2001-06-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:04896718-cfd3-4345-a8d7-f540b10ed24d
Source identifiers:
31875
Local pid:
pubs:31875

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