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Flagellum ontogeny in trypanosomes studied via an inherited and regulated RNA interference system.

Abstract:

The African trypanosome, Trypanosoma brucei possesses a large and unique intraflagellar structure called the paraflagellar rod (PFR). The PFR is composed of 2 major proteins, PFRA and PFRC. We have generated an inducible mutant trypanosome cell line (snl-2) that expresses linked inverted copies of a PFRA gene, capable of forming a PFRA double-stranded (ds) RNA. When expression of this dsRNA was induced, new PFRA RNA and PFRA protein quickly disappeared and PFR construction was affected, resul...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of cell science
Volume:
113 ( Pt 18)
Issue:
18
Pages:
3321-3328
Publication date:
2000-09-01
EISSN:
1477-9137
ISSN:
0021-9533
Source identifiers:
29819
Language:
English
Keywords:
Pubs id:
pubs:29819
UUID:
uuid:04884678-e5a5-4b85-8dbe-9d5024ab9ad2
Local pid:
pubs:29819
Deposit date:
2012-12-19

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