Journal article icon

Journal article

DICE 2: a further investigation of the effects of chance in life, death and subgroup analyses.

Abstract:

In an investigation into how chance might influence the distribution of deaths in a randomised trial and the time of those deaths, and to highlight the possible dangers of subgroup analyses, 100 randomised controlled trials were simulated and 50 subgroup pairs were simulated for some of these trials. Each of 580 control patients from a colorectal cancer trial was randomly coded to simulate allocation to treatment or control, the main outcome measure being time to death. Not surprisingly, most...

Expand abstract
Publication status:
Published

Actions


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Role:
Author
Journal:
International journal of clinical practice
Volume:
55
Issue:
4
Pages:
240-242
Publication date:
2001-05-05
EISSN:
1742-1241
ISSN:
1368-5031
URN:
uuid:0483054d-d071-46c4-ba54-467b5acf327f
Source identifiers:
49407
Local pid:
pubs:49407

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP