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Cranial irradiation for cerebral and nasopharyngeal tumours in children: evidence for the production of a hypothalamic defect in growth hormone release.

Abstract:

A synthetic 29-amino acid analogue of human pancreatic GH-releasing hormone (GHRH(1-29)NH2) has recently been shown to stimulate the release of GH in normal subjects. We have studied the GH response to GHRH(1-29)NH2 in nine children irradiated for brain and nasopharyngeal tumours, who were not growing and were deficient in GH as assessed by insulin-induced hypoglycaemia. Serum GH rose in response to GHRH(1-29)NH2 in all the children, and in five the peak serum GH response was greater than 20 ...

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Publication status:
Published

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Publisher copy:
10.1677/joe.0.1080025

Authors


Blacklay, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Savage, MO More by this author
Davies, PS More by this author
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Journal:
The Journal of endocrinology
Volume:
108
Issue:
1
Pages:
25-29
Publication date:
1986-01-05
DOI:
EISSN:
1479-6805
ISSN:
0022-0795
URN:
uuid:047a9284-6966-4beb-aecb-37a477405353
Source identifiers:
138510
Local pid:
pubs:138510

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