Journal article icon

Journal article

Cranial irradiation for cerebral and nasopharyngeal tumours in children: evidence for the production of a hypothalamic defect in growth hormone release.

Abstract:

A synthetic 29-amino acid analogue of human pancreatic GH-releasing hormone (GHRH(1-29)NH2) has recently been shown to stimulate the release of GH in normal subjects. We have studied the GH response to GHRH(1-29)NH2 in nine children irradiated for brain and nasopharyngeal tumours, who were not growing and were deficient in GH as assessed by insulin-induced hypoglycaemia. Serum GH rose in response to GHRH(1-29)NH2 in all the children, and in five the peak serum GH response was greater than 20 ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1677/joe.0.1080025

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Expand authors...
Journal:
Journal of endocrinology
Volume:
108
Issue:
1
Pages:
25-29
Publication date:
1986-01-01
DOI:
EISSN:
1479-6805
ISSN:
0022-0795
Source identifiers:
138510
Language:
English
Keywords:
Pubs id:
pubs:138510
UUID:
uuid:047a9284-6966-4beb-aecb-37a477405353
Local pid:
pubs:138510
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP