Beyond 'furballs' and 'dumpling soups' - towards a molecular architecture of signaling complexes and networks.

Journal article

The molecular architectures of intracellular signaling networks are largely unknown. Understanding their design principles and mechanisms of processing information is essential to grasp the molecular basis of virtually all biological processes. This is particularly challenging for human pathologies like cancers, as essentially each tumor is a unique disease with vastly deranged signaling networks. However, even in normal cells we know almost nothing. A few 'signalosomes', like the COP9 and th...

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Authors: Lewitzky, M; Simister, P; Feller, S

• Publication status: Published
• Journal: FEBS letters
• Volume: 586
• Issue: 17
• Pages: 2740-2750
• Publication date: 2012-08-01
• DOI: 10.1016/j.febslet.2012.04.029
• EISSN: 1873-3468
• ISSN: 0014-5793
• Language: English
• Keywords: Receptor, Epidermal Growth Factor; Insulin; Protein Interaction Mapping; Fungal Proteins; Humans; Insulin Receptor Substrate Proteins; Gene Expression Regulation; Animals; Computational Biology; Phosphoproteins; Neoplasms; Models, Biological; Receptor, Insulin; Signal Transduction