Animal models of anxiety and their molecular dissection.

Journal article

Genetic approaches to psychiatric illness need appropriate animal models both for investigating how genetic variants give rise to behavioural disorder and for identifying genes that may be important in human conditions. Yet the relevance of many animal models to psychiatric illness is often not clear. Here I discuss how genetic approaches can be used to validate animal models of anxiety, an approach which is applicable to other animal models. One drawback of genetic validation is the difficulty inherent in identifying the molecular variants that influence the phenotype. I review genetic approaches that have the potential to overcome this problem.

Authors: Flint, J

• Publication status: Published
• Journal: Seminars in cell and developmental biology
• Volume: 14
• Issue: 1
• Pages: 37-42
• Publication date: 2003-02-01
• DOI: 10.1016/S1084-9521(02)00170-2
• EISSN: 1096-3634
• ISSN: 1084-9521
• Language: English
• Keywords: Animals; Chromosome Mapping; Genetic Techniques; Anxiety Disorders; Disease Models, Animal; Anxiety