Journal article
Gain- and loss-of-function mutations in the breast cancer gene GATA3 result in differential drug sensitivity
- Abstract:
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Patterns of somatic mutations in cancer genes provide information about their functional role in tumourigenesis and thus indicate their potential for therapeutic exploitation. Yet, the classical distinction between oncogene and tumour suppressor may not always apply. For instance, TP53 has been simultaneously associated with tumour suppressing and promoting activities. Here, we uncover a similar phenomenon for GATA3, a frequently mutated, yet poorly understood breast cancer gene. We identify ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, zip, 12.5MB)
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(Version of record, pdf, 5.2MB)
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- Publisher copy:
- 10.1371/journal.pgen.1006279
Authors
Funding
+ DOC Fellowship of the Austrian Academy of Sciences
More from this funder
Funding agency for:
Mair, B
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Genetics Journal website
- Publication date:
- 2016-09-02
- Acceptance date:
- 2016-08-04
- DOI:
- EISSN:
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1553-7404
- ISSN:
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1553-7390
Item Description
- Pubs id:
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pubs:641604
- UUID:
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uuid:04685567-aec1-47f9-9586-e9c21ba1c08e
- Local pid:
- pubs:641604
- Source identifiers:
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641604
- Deposit date:
- 2016-09-06
Terms of use
- Copyright holder:
- Mair, et al
- Copyright date:
- 2016
- Notes:
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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