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Pluripotency factors regulate definitive endoderm specification through eomesodermin.

Abstract:

Understanding the molecular mechanisms controlling early cell fate decisions in mammals is a major objective toward the development of robust methods for the differentiation of human pluripotent stem cells into clinically relevant cell types. Here, we used human embryonic stem cells and mouse epiblast stem cells to study specification of definitive endoderm in vitro. Using a combination of whole-genome expression and chromatin immunoprecipitation (ChIP) deep sequencing (ChIP-seq) analyses, we...

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Publisher copy:
10.1101/gad.607311

Authors


Journal:
Genes and development More from this journal
Volume:
25
Issue:
3
Pages:
238-250
Publication date:
2011-02-01
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
Language:
English
Keywords:
Pubs id:
pubs:245636
UUID:
uuid:04652bba-3984-4ff5-8051-7f5c6accfd8f
Local pid:
pubs:245636
Source identifiers:
245636
Deposit date:
2012-12-19

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