Journal article
The role of clearance mechanisms in the kinetics of toxic protein aggregates involved in neurodegenerative diseases
- Abstract:
-
The deposition of pathological protein aggregates in the brain plays a central role in cognitive decline and structural damage associated with neurodegenerative diseases. In Alzheimer’s disease, the formation of Amyloid-beta plaques and neurofibrillary tangles of the tau protein is associated with the appearance of symptoms and pathology. Detailed models for the specific mechanisms of aggregate formation, such as nucleation and elongation, exist for aggregation in vitro where total protein ma...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- AIP Publishing Publisher's website
- Journal:
- Journal of Chemical Physics Journal website
- Volume:
- 154
- Issue:
- 12
- Article number:
- 125101
- Publication date:
- 2021-03-24
- Acceptance date:
- 2021-03-05
- DOI:
- EISSN:
-
1089-7690
- ISSN:
-
0021-9606
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1166519
- Local pid:
- pubs:1166519
- Deposit date:
- 2021-03-08
Terms of use
- Copyright holder:
- Thompson et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 Author(s). Published under license by AIP Publishing.
- Notes:
- This is the accepted manuscript version of the article. The final version is available from AIP Publishing at: https://doi.org/10.1063/5.0031650
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