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The role of clearance mechanisms in the kinetics of toxic protein aggregates involved in neurodegenerative diseases

Abstract:

The deposition of pathological protein aggregates in the brain plays a central role in cognitive decline and structural damage associated with neurodegenerative diseases. In Alzheimer’s disease, the formation of Amyloid-beta plaques and neurofibrillary tangles of the tau protein is associated with the appearance of symptoms and pathology. Detailed models for the specific mechanisms of aggregate formation, such as nucleation and elongation, exist for aggregation in vitro where total protein ma...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1063/5.0031650

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
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Name:
Engineering and Physical Sciences Research Council
Grant:
EP/R020205/1
Publisher:
AIP Publishing
Journal:
Journal of Chemical Physics More from this journal
Volume:
154
Issue:
12
Article number:
125101
Publication date:
2021-03-24
Acceptance date:
2021-03-05
DOI:
EISSN:
1089-7690
ISSN:
0021-9606
Language:
English
Keywords:
Pubs id:
1166519
Local pid:
pubs:1166519
Deposit date:
2021-03-08

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