Journal article icon

Journal article

Pathogenic mechanisms in murine autoimmune thyroiditis: short- and long-term effects of in vivo depletion of CD4+ and CD8+ cells.

Abstract:

Both murine CD4+ and CD8+ cells are found in the thyroid infiltrate in experimental autoimmune thyroiditis (EAT) induced with mouse thyroglobulin (MTg). MTg activation of immune cells in vitro enables CD4+ cells to transfer thyroiditis adoptively and to aid the cytotoxic capacity of CD8+ cells for thyroid monolayers. To dissect their relative contribution to pathogenesis in vivo, depleting doses of paired rat monoclonal antibodies (MoAb) recognizing two distinct CD4 or CD8 epitopes were injec...

Expand abstract
Publication status:
Published

Actions


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Expand authors...
Journal:
Clinical and experimental immunology
Volume:
77
Issue:
3
Pages:
428-433
Publication date:
1989-09-01
EISSN:
1365-2249
ISSN:
0009-9104
Source identifiers:
24322
Language:
English
Keywords:
Pubs id:
pubs:24322
UUID:
uuid:04510ce7-b73e-440a-b3cf-cad1d8b18fdc
Local pid:
pubs:24322
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP