Comparative and combined effects of transforming growth factors alpha and beta, interleukin-1 and interferon-gamma on rheumatoid synovial cell proliferation, glycolysis and prostaglandin E production.

Journal article

Enhanced cell proliferation, glycolysis and prostaglandin E production are all characteristic features of rheumatoid synovial tissue. The interrelationships of these three cellular parameters have been examined using rheumatoid synovial fibroblasts and their responses to specific cytokines in vitro. Transforming growth factor alpha (TGF alpha) caused a more than threefold increase in synovial cell proliferation whilst transforming growth factor beta (TGF beta), interleukin-1 alpha (IL-1 alpha...

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Authors: Taylor, D; Feldmann, M; Evanson, J; Woolley, D

• Publication status: Published
• Publisher: Springer-Verlag
• Journal: Rheumatology international
• Volume: 9
• Issue: 2
• Pages: 65-70
• Publication date: 1989-01-01
• DOI: 10.1007/bf00270247
• EISSN: 1437-160X
• ISSN: 0172-8172
• Language: English
• Keywords: Interleukin-1; Cell Division; Interferon-gamma; Synovial Membrane; Biological Factors; Rheumatic Diseases; Prostaglandins E; Glycolysis; Humans; Transforming Growth Factors; Cytokines