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Journal article

Genetic analysis of autoimmune type 1 diabetes mellitus in mice.

Abstract:
Two genes, Idd-3 and Idd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the chromosome 17 major histocompatibility complex. A genetic map of the mouse genome, analysed using the polymerase chain reaction, has been assembled specifically for the study. On the basis of comparative maps of the mouse and human genomes, the homologue of Idd-3 may reside on human chromosomes 1 or 4 and Idd-4 on chromosome 17.
Publication status:
Published

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Publisher copy:
10.1038/351542a0

Authors


Aitman, TJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, CCMP
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Journal:
Nature
Volume:
351
Issue:
6327
Pages:
542-547
Publication date:
1991-06-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:04482513-2a05-4e6a-8897-3d70345f132a
Source identifiers:
30829
Local pid:
pubs:30829

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