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A mathematical model of the slow force response to stretch in rat ventricular myocytes

Abstract:

We developed a model of the rat ventricular myocyte at room temperature to predict the relative effects of different mechanisms on the cause of the slow increase in force in response to a step change in muscle length. We performed simulations in the presence of stretch-dependent increases in flux through the Na(+)-H(+) exchanger (NHE) and Cl(-)-HCO(3)(-) exchanger (AE), stretch-activated channels (SAC), and the stretch-dependent nitric oxide (NO) induced increased open probability of the ryan...

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Authors


S.A. Niederer More by this author
N.P. Smith More by this author
Journal:
Biophys J
Volume:
92
Issue:
11
Pages:
4030-44
Publication date:
2007
URN:
uuid:04435aa5-cc63-4f76-9c50-3b2253652667
Local pid:
cs:1525

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