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Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains.

Abstract:

The superfamily of prokaryotic inwardly rectifying (KirBac) potassium channels is homologous to mammalian Kir channels. However, relatively little is known about their regulation or about their physiological role in vivo. In this study, we have used random mutagenesis and genetic complementation in K(+)-auxotrophic Escherichia coli and Saccharomyces cerevisiae to identify activatory mutations in a range of different KirBac channels. We also show that the KirBac6.1 gene (slr5078) is necessary ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m110.175687

Authors


Paynter, JJ More by this author
Andres-Enguix, I More by this author
Fowler, PW More by this author
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Journal:
The Journal of biological chemistry
Volume:
285
Issue:
52
Pages:
40754-40761
Publication date:
2010-12-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:044093ce-946e-44c7-a0b2-46d607260d32
Source identifiers:
83816
Local pid:
pubs:83816

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