- Abstract:
-
The superfamily of prokaryotic inwardly rectifying (KirBac) potassium channels is homologous to mammalian Kir channels. However, relatively little is known about their regulation or about their physiological role in vivo. In this study, we have used random mutagenesis and genetic complementation in K(+)-auxotrophic Escherichia coli and Saccharomyces cerevisiae to identify activatory mutations in a range of different KirBac channels. We also show that the KirBac6.1 gene (slr5078) is necessary ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m110.175687
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 285
- Issue:
- 52
- Pages:
- 40754-40761
- Publication date:
- 2010-12-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
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0021-9258
- URN:
-
uuid:044093ce-946e-44c7-a0b2-46d607260d32
- Source identifiers:
-
83816
- Local pid:
- pubs:83816
- Copyright date:
- 2010
Journal article
Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains.
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