Journal article icon

Journal article

Active viral genes in transformed cells lie close to the nuclear cage.

Abstract:

Nuclear DNA is looped by attachment to a matrix or cage. Using nine different lines transformed by polyoma or avian sarcoma virus, we have mapped viral sequences integrated within these loops. In all lines that contain high concentrations of viral transcripts and express the transformed phenotype, the integrated viral genes lie close to the points of attachment to the cage. Integration of polyoma DNA induces outlying cellular sequences to become closely associated with the cage. The strength ...

Expand abstract
Publication status:
Published

Actions


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Expand authors...
Journal:
The EMBO journal
Volume:
1
Issue:
4
Pages:
447-452
Publication date:
1982
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:043d06d0-dc1c-47f5-8843-dfc2d45ae157
Source identifiers:
3677
Local pid:
pubs:3677

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP