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Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue.

Abstract:

A missense C1858T single nucleotide polymorphism in the PTPN22 gene recently emerged as a major risk factor for human autoimmunity. PTPN22 encodes the lymphoid tyrosine phosphatase (LYP), which forms a complex with the kinase Csk and is a critical negative regulator of signaling through the T cell receptor. The C1858T single nucleotide polymorphism results in the LYP-R620W variation within the LYP-Csk interaction motif. LYP-W620 exhibits a greatly reduced interaction with Csk and is a gain-of...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m110.111104

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Journal:
Journal of biological chemistry
Volume:
285
Issue:
34
Pages:
26506-26518
Publication date:
2010-08-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
60459

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