- Abstract:
-
A missense C1858T single nucleotide polymorphism in the PTPN22 gene recently emerged as a major risk factor for human autoimmunity. PTPN22 encodes the lymphoid tyrosine phosphatase (LYP), which forms a complex with the kinase Csk and is a critical negative regulator of signaling through the T cell receptor. The C1858T single nucleotide polymorphism results in the LYP-R620W variation within the LYP-Csk interaction motif. LYP-W620 exhibits a greatly reduced interaction with Csk and is a gain-of...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m110.111104
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 285
- Issue:
- 34
- Pages:
- 26506-26518
- Publication date:
- 2010-08-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:043b2e77-c4db-4c2d-a8cc-d7659c657bd3
- Source identifiers:
-
60459
- Local pid:
- pubs:60459
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue.
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