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Thesis

Antiviral mechanisms of small molecules targeting the endoplasmic reticulum and Golgi apparatus

Abstract:

N-linked glycosylation is the most common form of post-translational modification in nature and is essential to almost all enveloped viruses, including members of the Flaviviridae family. The host cell N-linked glycoprotein processing pathway is utilised by these viruses and as such has long been identified as a potential target for the development of antiviral drugs. Here, the antiviral mechanisms of three classes of small molecules targeting the secretory pathway and altering viral envelope...

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Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Oxford college:
Linacre College
Department:
Medical Sciences Division - Biochemistry
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:04368b4b-2fd3-4fc7-8f89-ec39cd87e37d
Local pid:
ora:11843

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