Antiviral mechanisms of small molecules targeting the endoplasmic reticulum and Golgi apparatus

Thesis

N-linked glycosylation is the most common form of post-translational modification in nature and is essential to almost all enveloped viruses, including members of the Flaviviridae family. The host cell N-linked glycoprotein processing pathway is utilised by these viruses and as such has long been identified as a potential target for the development of antiviral drugs. Here, the antiviral mechanisms of three classes of small molecules targeting the secretory pathway and altering viral envelope...

Expand abstract

Authors: Howe, J; Jonathon David Howe

• Publication date: 2014
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: Glycobiology; Antiviral mechanisms; Glycosidase Inhibitors; Biochemistry
• Subjects: Glycobiology; Biochemistry