Fatty acid-induced mitochondrial uncoupling in adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative capacity is increased.

Journal article

The release of fatty acids from white adipose tissue is regulated at several levels. We have examined the suggestion that fatty acid release might be diminished by upregulation of mitochondrial fatty acid oxidation in the adipocyte, through increasing mitochondrial uncoupling. The intrinsic oxidative capacity of white adipose tissue is low, and older studies suggest that there is little fatty acid oxidation in white adipocytes, human or rodent. We have examined data on fatty acid metabolism a...

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Authors: Frayn, K; Langin, D; Karpe, F

• Publication status: Published
• Journal: Diabetologia
• Volume: 51
• Issue: 3
• Pages: 394-397
• Publication date: 2008-03-01
• DOI: 10.1007/s00125-007-0901-z
• EISSN: 1432-0428
• ISSN: 0012-186X
• Language: English
• Keywords: Uncoupling Agents; Animals; Insulin Resistance; Oxidative Phosphorylation; Adipocytes; Mitochondria; Oxygen Consumption; Fatty Acids; Models, Biological; Humans; Adipose Tissue, Brown