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Structural and functional consequences of age-related isomerization in α-crystallins

Abstract:

Long-lived proteins are subject to spontaneous degradation and may accumulate a range of modifications over time, including subtle alterations such as side-chain isomerization. Recently, tandem MS has enabled identification and characterization of such peptide isomers, including those differing only in chirality. However, the structural and functional consequences of these perturbations remain largely unexplored. Here, we examined the impact of isomerization of aspartic acid or epimerization ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.ra118.007052

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Oxford college:
University College
Role:
Author
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Name:
Engineering & Physical Sciences Research Council
Grant:
EP/J01835X/1
Publisher:
American Society for Biochemistry and Molecular Biology
Journal:
Journal of Biological Chemistry More from this journal
Volume:
294
Pages:
7546-7555
Publication date:
2019-02-25
Acceptance date:
2019-02-25
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pmid:
30804217
Language:
English
Keywords:
Pubs id:
pubs:980510
UUID:
uuid:042e78db-af28-4503-9479-52effe3f51a6
Local pid:
pubs:980510
Source identifiers:
980510
Deposit date:
2019-04-22

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