Similar nociceptive afferents mediate psychophysical and electrophysiological responses to heat stimulation of glabrous and hairy skin in humans.

Journal article

The ability to perceive and withdraw rapidly from noxious environmental stimuli is crucial for survival. When heat stimuli are applied to primate hairy skin, first pain sensation is mediated by type-II A-fibre nociceptors (II-AMHs). In contrast, the reported absence of first pain and II-AMH microneurographical responses when heat stimuli are applied to the hand palm has led to the notion that II-AMHs are lacking in this primate glabrous skin. The aim of this study was to assess the effect of ...

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Authors: Iannetti, G; Zambreanu, L; Tracey, I

• Publication status: Published
• Journal: Journal of physiology
• Volume: 577
• Issue: Pt 1
• Pages: 235-248
• Publication date: 2006-11-01
• DOI: 10.1113/jphysiol.2006.115675
• EISSN: 1469-7793
• ISSN: 0022-3751
• Language: English
• Keywords: Adult; Hot Temperature; Male; Skin; Evoked Potentials, Somatosensory; Humans; Female; Physical Stimulation; Nociceptors; Afferent Pathways; Skin Physiological Phenomena; Pain Threshold