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A comparison of the effects of the novel muscarinic receptor agonists L-689,660 and AF102B in tests of reference and working memory.

Abstract:

Four experiments compared the CNS effects of a novel M1/M3 receptor agonist L-689,660 with those of the M1/M3 muscarinic receptor agonist AF102B. In the mouse tail-flick test of antinociception (TF) the minimum effective doses to increase tail-flick latency (MED) of L-689,660 and AF102B were 0.03 mg/kg and 10.0 mg/kg, respectively. In a rat conditioned-suppression-of-drinking (CSD) test of reference memory, doses of 0.3 and 1.0 mg/kg L-689,660 and a dose of 5.0 mg/kg AF102B reversed a scopola...

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Publication status:
Published

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Publisher copy:
10.1007/bf02245210

Authors


Dawson, GR More by this author
Channell, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Psychopharmacology
Volume:
113
Issue:
3-4
Pages:
361-368
Publication date:
1994-01-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:041ac527-c79c-424b-b0ec-769191aee587
Source identifiers:
16612
Local pid:
pubs:16612

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