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Kinetics of the natural, humoral immune response to Salmonella enterica serovar Typhi in Kathmandu, Nepal

Abstract:

Typhoid fever is a major public health problem in developing countries, conservatively estimated to occur in 17 million cases and be responsible for 200,000 deaths annually. We investigated the acquisition of natural immunity to Salmonella enterica serovar Typhi in a region where typhoid is endemic by testing sera from an age-stratified sample of 210 healthy participants in Kathmandu, Nepal, for bactericidal activity toward S. Typhi and for anti-Vi capsular polysaccharide antibodies....

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/CVI.00245-09

Authors


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Institution:
University of Oxford
Research group:
Oxford Vaccine Group
Department:
Medical Sciences Division - Paediatrics,Department of
More by this author
Institution:
Patan Hospital, Kathmandu, Nepal
Department:
Departments of Paediatrics and Internal Medicine
More by this author
Institution:
University of Oxford
Research group:
Oxford Vaccine Group
Department:
Medical Sciences Division - Paediatrics,Department of
More by this author
Institution:
Patan Hospital, Kathmandu, Nepal
Department:
Departments of Paediatrics and Internal Medicine
More by this author
Institution:
Patan Hospital, Kathmandu, Nepal
Department:
Departments of Paediatrics and Internal Medicine
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Funding agency for:
Andrew J. Pollard
Department of Health's NIHR Biomedical Research Centres Programme More from this funder
Peel Medical Trust, UK More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Clinical and Vaccine Immunology Journal website
Volume:
16
Issue:
10
Pages:
1413-1419
Publication date:
2009-10-05
DOI:
EISSN:
1556-679X
ISSN:
1556-6811
URN:
uuid:041820ff-e9e9-4d8f-86c4-ef355e6c85d6
Local pid:
ora:4159
Language:
English
Keywords:
Subjects:

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