Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation.

Journal article

FoxP3(+) confers suppressive properties and is confined to regulatory T cells (T(reg)) that potently inhibit autoreactive immune responses. In the transplant setting, natural CD4(+) T(reg) are critical in controlling alloreactivity and the establishment of tolerance. We now identify an important CD8(+) population of FoxP3(+) T(reg) that convert from CD8(+) conventional donor T cells after allogeneic but not syngeneic bone marrow transplantation. These CD8(+) T(reg) undergo conversion in the m...

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Authors: Robb, R; Lineburg, K; Kuns, R; Wilson, Y; Raffelt, N

• Publication status: Published
• Journal: Blood
• Volume: 119
• Issue: 24
• Pages: 5898-5908
• Publication date: 2012-06-01
• DOI: 10.1182/blood-2011-12-396119
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Immune Tolerance; Cell Proliferation; Dendritic Cells; Antibodies; CD8-Positive T-Lymphocytes; Cell Differentiation; Bone Marrow Transplantation; Forkhead Transcription Factors; Phenotype; Transforming Growth Factor beta; Sirolimus; Female; Lymph Nodes; Interleukin-2; Survival Analysis; Animals; Epitopes; Graft vs Host Disease; Mice, Inbred C57BL; Mice; Transplantation, Homologous; T-Lymphocytes, Regulatory