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Regulation of cell cycle and stress responses to hydrostatic pressure in fission yeast.

Abstract:

We have investigated the cellular responses to hydrostatic pressure by using the fission yeast Schizosaccharomyces pombe as a model system. Exposure to sublethal levels of hydrostatic pressure resulted in G2 cell cycle delay. This delay resulted from Cdc2 tyrosine-15 (Y-15) phosphorylation, and it was abrogated by simultaneous disruption of the Cdc2 kinase regulators Cdc25 and Wee1. However, cell cycle delay was independent of the DNA damage, cytokinesis, and cell size checkpoints, suggesting...

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Publication status:
Published

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Publisher copy:
10.1091/mbc.e06-12-1141

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Journal:
Molecular biology of the cell
Volume:
18
Issue:
10
Pages:
4168-4179
Publication date:
2007-10-01
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
Source identifiers:
315393
Language:
English
Keywords:
Pubs id:
pubs:315393
UUID:
uuid:041617e8-47bb-43b6-af73-4e661d7183dc
Local pid:
pubs:315393
Deposit date:
2013-11-17

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