Alpha-synuclein dysfunction in Lewy body diseases.

Journal article

alpha-Synuclein belongs to a small group of natively unfolded proteins that can transiently bind to lipid membranes and acquire a partial alpha-helical conformation. Its relevance to Parkinson's disease (PD) is based on mutations found in familial cases of the disease and its presence in filaments of Lewy bodies (LB) and Lewy neurites (LN) in sporadic cases where it is packed in a beta-sheet configuration. This structural plasticity of alpha-synuclein has raised the possibility that neurodege...

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Authors: Tofaris, G; Spillantini, MG

• Journal: Movement disorders : official journal of the Movement Disorder Society
• Volume: 20 Suppl 12
• Issue: SUPPL. 12
• Pages: S37-S44
• Publication date: 2005-08-01
• DOI: 10.1002/mds.20538
• EISSN: 1531-8257
• ISSN: 0885-3185
• Language: English
• Keywords: Point Mutation; alpha-Synuclein; Animals; Chromosomes, Human, Pair 6; Mice; Parkinson Disease; Phenotype; Phosphorylation; Humans; Drosophila; Cytoskeleton; Lewy Body Disease