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Alpha-synuclein dysfunction in Lewy body diseases.

Abstract:

alpha-Synuclein belongs to a small group of natively unfolded proteins that can transiently bind to lipid membranes and acquire a partial alpha-helical conformation. Its relevance to Parkinson's disease (PD) is based on mutations found in familial cases of the disease and its presence in filaments of Lewy bodies (LB) and Lewy neurites (LN) in sporadic cases where it is packed in a beta-sheet configuration. This structural plasticity of alpha-synuclein has raised the possibility that neurodege...

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Publisher copy:
10.1002/mds.20538
Journal:
Movement disorders : official journal of the Movement Disorder Society More from this journal
Volume:
20 Suppl 12
Issue:
SUPPL. 12
Pages:
S37-S44
Publication date:
2005-08-01
DOI:
EISSN:
1531-8257
ISSN:
0885-3185
Language:
English
Keywords:
Pubs id:
pubs:241045
UUID:
uuid:04052447-e354-4bcb-8a17-0970dcc092a8
Local pid:
pubs:241045
Source identifiers:
241045
Deposit date:
2014-02-08

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