Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia.

Journal article

High hyperdiploidy (HeH) (51 to 65 chromosomes) is found in one third of children with acute lymphoblastic leukemia and is associated with a good prognosis. Cytogenetic features may further refine this prognosis and identify patients with a poor outcome. We examined the effect of sex, age, individual trisomies, modal number, and structural abnormalities on survival among 700 children with HeH. Univariate analysis showed that age. sex, +4, +10, +18, and a high modal number were associated with...

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Authors: Moorman, A; Richards, S; Martineau, M; Cheung, K; Robinson, H

• Publication status: Published
• Journal: Blood
• Volume: 102
• Issue: 8
• Pages: 2756-2762
• Publication date: 2003-10-01
• DOI: 10.1182/blood-2003-04-1128
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Trisomy; Age Factors; Diploidy; Child; Adolescent; Proportional Hazards Models; Child, Preschool; Humans; Male; Karyotyping; Disease-Free Survival; Female; United Kingdom Medical Research Council's Childhood Leukemia Working Party; Time Factors; Treatment Outcome; Infant; Prognosis; Sex Factors; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Multivariate Analysis; In Situ Hybridization, Fluorescence