WCB is a C2 domain protein defining the plasma membrane - sub-pellicular microtubule corset of kinetoplastid parasites.

Journal article

WCB is a protein that locates between the inner face of the plasma membrane and the sub-pellicular corset of microtubules in Trypanosoma brucei. We provide the molecular identity of WCB and bioinformatic analysis suggests that it possesses a C2 domain implicated in membrane/protein interactions and a highly charged region possessing characteristics of a putative tubulin-binding domain. Functional analyses via RNA interference (RNAi) depletion show that WCB is essential for cell morphogenesis....

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Authors: Baines, A; Gull, K

• Publication status: Published
• Journal: Protist
• Volume: 159
• Issue: 1
• Pages: 115-125
• Publication date: 2008-01-01
• DOI: 10.1016/j.protis.2007.09.001
• EISSN: 1618-0941
• ISSN: 1434-4610
• Language: English
• Keywords: Microtubules; Cell Membrane; Molecular Sequence Data; Trypanosoma brucei brucei; Blotting, Western; Microscopy, Electron, Transmission; Protozoan Proteins; Amino Acid Sequence; Animals