Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax malaria during and after pregnancy.

Journal article

Amodiaquine is effective for the treatment of Plasmodium vivax malaria, but there is little information on the pharmacokinetic and pharmacodynamic properties of amodiaquine in pregnant women with malaria. This study evaluated the population pharmacokinetic and pharmacodynamic properties of amodiaquine and its biologically active metabolite, desethylamodiaquine, in pregnant women with P. vivax infection and again after delivery. Twenty-seven pregnant women infected with P. vivax malaria on the...

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Authors: Tarning, J; Chotsiri, P; Jullien, V; Rijken, M; Bergstrand, M

• Publication status: Published
• Journal: Antimicrobial agents and chemotherapy
• Volume: 56
• Issue: 11
• Pages: 5764-5773
• Publication date: 2012-11-01
• DOI: 10.1128/aac.01242-12
• EISSN: 1098-6596
• ISSN: 0066-4804
• Language: English
• Keywords: Plasmodium vivax; Female; Biotransformation; Adult; Amodiaquine; Pregnancy; Antimalarials; Drug Administration Schedule; Pregnancy Complications, Parasitic; Body Weight; Humans; Adolescent; Malaria, Vivax; Recurrence; Nonlinear Dynamics